• Endocannabinoid System (ECS)

    The ECS is a complex cell-signaling system found in humans and other mammals. It plays a crucial role in regulating various physiological processes, maintaining homeostasis, and responding to external stimuli.

  • CBD and ECS Receptors

    Cannabidiol (CBD), a phytocannabinoid found in the Cannabis sativa plant, interacts with the ECS. It engages primarily with two types of receptors: CB1 receptors, predominantly present in the central nervous system, and CB2 receptors, mainly found in the peripheral tissues and immune cells.

  • CB1 Receptors and Neurotransmission

    CBD's interaction with CB1 receptors in the brain influences neurotransmission. Unlike THC, CBD has a low affinity for CB1 receptors, exerting a modulating influence without inducing the characteristic psychoactive effects.

  • CB2 Receptors and Immune Modulation

    CBD's interaction with CB2 receptors, prevalent in the immune system, contributes to its immunomodulatory effects. This interaction may play a role in mitigating inflammatory responses and supporting immune function.

  • Serotonin Receptors (5-HT1A)

    CBD acts as an agonist at serotonin receptors, particularly 5-HT1A receptors. This interaction influences serotonin levels and is associated with potential anxiolytic effects, contributing to mood regulation.

  • Vanilloid Receptors (TRPV1)

    CBD interacts with TRPV1 receptors, known for their role in pain perception, inflammation, and temperature regulation. This interaction contributes to CBD's potential analgesic and anti-inflammatory properties.

  • GABAergic System Modulation

    CBD's modulation of the GABAergic system involves enhancing the effects of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter. This modulation contributes to the calming and anti-anxiety effects attributed to CBD.

  • Glutamate and Neuroprotective Effects

    CBD modulates glutamate signaling, impacting excitatory neurotransmission. This modulation is linked to potential neuroprotective effects, safeguarding against neurodegenerative processes.

  • Inhibition of Enzymes

    CBD inhibits enzymes like fatty acid amide hydrolase (FAAH), responsible for breaking down endocannabinoids like anandamide. This inhibition elevates anandamide levels, contributing to mood regulation and pain modulation.

  • Anti-Inflammatory and Immunomodulatory Mechanisms

    CBD's interaction with CB2 receptors, immune cells, and cytokines contributes to its anti-inflammatory and immunomodulatory effects. This makes CBD a subject of interest in conditions characterized by inflammation and immune dysregulation.

  • Antioxidant Properties

    CBD's antioxidant properties are believed to contribute to its potential neuroprotective effects, protecting against oxidative stress and supporting overall brain health.

  • Biphasic Dose Response

    CBD exhibits a biphasic dose-response curve, implying that its effects can vary based on the dosage. Low to moderate doses may have different effects compared to higher doses, emphasizing the importance of dosage considerations.

  • HPA Axis Modulation

    CBD may modulate the hypothalamic-pituitary-adrenal (HPA) axis, the central player in the body's stress response. This modulation contributes to CBD's potential anti-anxiety effects.

  • Safety Profile

    CBD is generally well-tolerated, with few reported side effects. However, considering potential interactions with medications, it's advisable for individuals to consult healthcare professionals before integrating CBD into their regimen.

CBD's multifaceted mechanisms involve intricate interactions with the ECS, neurotransmitter systems, and various receptors throughout the body. Ongoing research continues to unveil the full spectrum of CBD's therapeutic potential and its applications across diverse medical contexts.

  • Manufactured in the USA

    All CleanAF CBD products are filled, assembled and packaged at our manufacturing facility in Clearwater, FL.

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  • Independently Lab Tested

    All of our products are third-party lab tested to ensure everything you use that bears our name is accurately labeled and safe to use.

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  • Quality Guaranteed

    Every CleanAF CBD product comes with a 100% Quality Guarantee. If you ever run into issues - Please let us know!

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